Cotylenin a是什么

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August undefined, 2024

WebAug 14, 2008 · Cotylenin A, a plant growth regulator, and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), are potent inducers of differentiation of myeloid … WebJul 1, 2008 · Cotylenin A or IPA immediately induced the expression of S100P mRNA and protein, and the differentiation of HL-60 cells was suppressed by treatment with antisense oligonucleotides against S100P, which suggests that S100P plays an important role in cell differentiation [28]. Cotylenin A enhanced the LCA acetate-induced differentiation …

Cotylenin A, a Differentiation-inducing Agent, and IFN-α …

WebNov 18, 2014 · Arsenic trioxide (ATO) is an approved treatment for acute promyelocytic leukemia (APL). It has also shown potential for treatment of multiple myeloma and various solid tumors including breast cancer. The requirement of high, toxic concentrations for the induction of apoptosis in non-APL and solid tumor cells is a major limitation for its use in … WebSep 28, 2024 · Cotylenin A and fusicoccin A are two flagship members of the fusicoccane diterpenoid family that are capable of acting as molecular glues to stabilize the … spas in rolla missouri

Investigating the effect of insect conditioned medium and its ...

WebMay 12, 2024 · More information: Masahiro Uwamori et al, Enantioselective Total Synthesis of Cotylenin A, Journal of the American Chemical Society (2024).DOI: 10.1021/jacs.0c01774 WebMar 8, 2024 · Cotylenin A is a glycosylated diterpene, which was isolated from the metabolites of Cladosporium sp. 501-7W, as a plant growth regulator. 5 Biological … WebSep 29, 1997 · Cotylenins had been isolated as the plant-growth regulators, and have been found to affect a number of physiological processes of higher plants. Here we report that … technical reproduction benjamin

Convergent Total Synthesis of (+)-Cotylenin A SpringerLink

Total synthesis of cotylenin A for a new anticancer …

WebJul 1, 2003 · Cotylenin A, a Differentiation-inducing Agent, and IFN-α Cooperatively Induce Apoptosis and Have an Antitumor Effect on Human Non-Small Cell Lung Carcinoma … WebSep 29, 1997 · Cotylenins had been isolated as the plant-growth regulators, and have been found to affect a number of physiological processes of higher plants. Here we report that … technical report of purifier overhaulWebJul 1, 2003 · Cotylenin A, a novel inducer of the differentiation of leukemia cells, and IFN-alpha synergistically inhibited the growth of and induced apoptosis in several human non-small cell lung carcinoma cell lines, suggesting that this combination may have therapeutic value in treating lung cancer. Cotylenin A, a novel inducer of the differentiation of … spas in rowley ma

"WebCotylenin A, a plant growth regulator, and rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), are potent inducers of differentiation of myeloid leukemia … " - Cotylenin a是什么

Cotylenin a是什么

Induction of the monocytic differentiation of myeloid leukaemia cells ...

WebAn organic chemistry minilecture on the Enantioselective Total Synthesis of Cotylenin A by Masahiro Uwamori, Ryunosuke Osada, Ryoji Sugiyama, Kotaro Nagatani... WebNov 18, 2014 · In the present study, we found that cotylenin A, a plant growth regulator and a potent inducer of differentiation in myeloid leukemia cells, significantly potentiated both ATO-induced inhibition of cell growth in a liquid culture, and ATO-induced inhibition of anchorage-independent growth in a semi-solid culture in human breast cancer MCF-7 …

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WebMay 13, 2024 · An anticancer drug of fungal origin could be the way. Scientists at Waseda University succeeded in developing a method for a total synthesis of cotylenin A, a plant … WebDec 6, 2014 · Introduction: Multiple myeloma is still incurable and optimize existing chemotherapeutic strategies and development of novel agents are necessary to improve the outcome of patients.Cotylenin A, a fusicoccane diterpene glycoside with a complex sugar moiety, was isolated as a plant-growth regulator. Cotylenin A modulates the 14-3-3 …

WebMar 19, 2024 · Cotylenin A (pictured) was originally isolated from a fungus. It is bioactive and can act as a plant growth regulator and an anti-cancer agent. While its absolute structure has been determined using X-ray crystallography, no total synthesis of cotylenin A had been reported so far. Only the total synthesis of the related cotylenol, which misses ... WebJul 14, 2024 · Cotylenin A and fusicoccin A (Fig. 7.1) are structurally related diterpene glucosides, which were isolated from different sources of Cladosporium sp. 501-7 W …

WebSep 28, 2024 · Small molecules that modulate the 14-3-3 protein-protein interaction (PPI) network represent valuable therapeutics and tool com-pounds. However, access has been lost to 14-3-3 PPI molecular glues of … WebA convergent enantioselective total synthesis of cotylenin A is described. The A-ring fragment, prepared via the catalytic asymmetric intramolecular cyclopropanation developed in our laboratory, and the C-ring fragment, prepared from a known chiral compound via a modified acyl radical cyclization, were successfully assembled by the Utimoto coupling …

WebMar 8, 2024 · Cotylenin A is a glycosylated diterpene, which was isolated from the metabolites of Cladosporium sp. 501-7W, as a plant growth regulator. 5 Biological studies on cotylenin A have revealed that it induces apoptosis in a wide range of human cancer cell lines by combined treatment with interferon-α. 6 The promising bioactivity and the …

WebJul 1, 2003 · Abstract. Cotylenin A, a novel inducer of the differentiation of leukemia cells, and IFN-α synergistically inhibited the growth of and induced apoptosis in several human non-small cell lung carcinoma cell lines. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor DR5 were the early genes induced by the combination of … technical report dfoWebCurrent Weather. 5:11 AM. 47° F. RealFeel® 48°. Air Quality Excellent. Wind NE 2 mph. Wind Gusts 5 mph. Clear More Details. technical report eappWebJan 1, 1998 · The structure of cotylenin A, a potent plant-growth stimulant with the most complex molecule in cotylenins from Cladosporium fungus sp. 501-7W, was analyzed … spas in richmond va short pumpWebMay 13, 2024 · An anticancer drug of fungal origin could be the way. Scientists at Waseda University succeeded in developing a method for a total synthesis of cotylenin A, a plant growth regulator which has ... technical report tpriWebDec 20, 2001 · Cotylenin A did not affect the erythroid or megakaryocytic differentiation of leukaemia cells. 12‐O‐tetradecanoyl phorbol‐13‐acetate (TPA) is a potent inducer of monocytic differentiation, but also induces megakaryocytic differentiation (Tabillio et al, 1983; Alitalo et al, 1988). These results indicate that cotylenin A is a potent and ... spas in rockwall txWebAlso, cotylenin A has a complex structure where two carbocyclic five-membered rings are fused with a formidable carbocyclic eight-membered ring with a uniquely-structured, glucose-based sugar ... spas in rosemont il technical requirements gathering questions