WebIdentification of posttreatment controllers among SIV-infected rhesus macaques. Among different studies performed at the Yerkes National Primate Research Center in which rhesus macaques (RMs) were experimentally infected with SIV, initiated on ART, and underwent analytic treatment interruption (ATI), we identified 7 RMs with superior ability to control … WebJun 9, 2024 · Treating macaques with an anti-α4β7 antibody under the umbrella of combination antiretroviral therapy (cART) during early SIV infection can lead to viral remission, with viral loads maintained ...
Early treatment with anti-α4β7 antibody facilitates increased …
WebSep 6, 2024 · treatment to treatment with non-neutralizing monoclonal antibodies against the SIV envelope glycoprotein that only block a4b7 binding to SIV Env but have no other host-directed effects. Similar to the initial study, we used an attenuated strain of SIVcontaining a stop codon in nef.The study used 30 macaques that all began … WebOct 1, 2024 · In this paper, we used SIV-infected rhesus macaques as a model to study the development of neutralization breadth by infecting rhesus macaques with longitudinal NAb escape variants and evaluating the kinetics of NAb response and viral evolution. We found that the infected macaques developed a stepwise NAb response against escape … simplicity 9237
Antibody therapy leads to sustained post-treatment SIV control in macaques
WebNov 17, 1995 · The efficacy of pre- and postexposure treatment with the antiviral compound (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) was tested against simian immunodeficiency virus (SIV) in macaques as a model for human immunodeficiency virus (HIV).PMPA was administered subcutaneously once daily beginning either 48 hours … WebLast year, Bieniasz and Hatziioannou discovered that pigtail macaques, a species of medium-sized monkeys from Southeast Asia, carried a mutant form of TRIM5 that fails to inactivate HIV. “This was a key insight,” said Bieniasz. “This mutation stops TRIM5 from preventing HIV infection. So with pigtail macaques, unlike other monkey species ... WebDec 20, 2024 · Imaging cohorts. PET/CT imaging studies were carried out on representative animals from three separate treatment cohorts of SIV infected macaques that were treated with α 4 β 7 mAb ... simplicity 9234