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Myocaf

WebAnne Rafferty ... / Anne Rafferty WebNov 9, 2024 · Raw Blame. ## "Extricating human tumor-enriched immune alterations from non-malignant tissue inflammation". ## Script for integrating scRNA-seq data from OM and HNSCC samples. ## Input CD3+ sorted T population as well as Lin-HLADR+ population. ## Florian Mair, last updated 2024-11-09.

单细胞转录组揭示乳头状甲状腺癌起始与发展 - 腾讯云开发者社区

WebDec 1, 2024 · myoCAF – promoting tumour progression and therapy resistance. Pan-cancer analyses of bulk transcriptomic and single-cell data have shown that myoCAFs are … WebOct 18, 2024 · To assess the potential transcriptional diversity of fibroblasts in PTCs, we constructed an myoCAF module and an iCAF module with the myoCAFs and iCAFs … host microbiome https://haleyneufeldphotography.com

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WebJan 31, 2024 · Two major CAF subpopulations have been described in several cancer types: myofibroblastic-CAFs (myoCAFs) and inflammatory-CAFs (iCAFs) 7, 8. The role of these CAF subpopulations remains poorly... http://perspectives09.myocaf.com/pottery_static_gallery/Fro_dest2/pages/Katy%20McDougal.htm WebMyofibroblastic cancer-associated fibroblast (myoCAF)–rich tumors generally contain few T cells and respond poorly to immune-checkpoint blockade. Although myoCAFs are associated with poor outcome... host microbiota

Single-cell RNA sequencing highlights the functional role of …

Category:Inflammatory cell-derived CXCL3 promotes pancreatic …

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Myocaf

Single-cell transcriptomic analysis of the tumor …

WebApr 11, 2024 · Growing evidence demonstrates that cancer-associated fibroblasts (CAF) are responsible for tumor genesis, growth, metastasis, and treatment response. Therefore, targeting these cells may contribute to tumor control. It has been proposed that targeting key molecules and pathways of proliferative functions can be more effective than killing … WebDec 1, 2024 · Myofibroblastic CAF (myoCAF) are analogous to myofibroblasts found in wound-healing and tissue fibrosis. These contractile, secretory cells are regulated through TGFβ1 signaling, express α-smooth muscle actin (SMA), and secrete collagen-rich extracellular matrix (ECM; refs. 2, 3 ).

Myocaf

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WebOct 26, 2024 · According to the previous researches, 10 markers of myoCAF (ACTA2, TAGLN, MMP11, MYL9, HOPX, POSTN, TPM1, TPM2, IGFBP7, and CST1) and 10 markers of iCAF (PLA2G2A, CCDC80, MCL1, S100A10, LMNA, UAP1, DPT, ABL2, EFEMP1 and TNFAIP6) were selected in TCGA-THCA dataset.

http://perspectives09.myocaf.com/pottery_static_gallery/Fro_dest2/pages/Anne%20Rafferty.htm WebMar 23, 2024 · Main Pancreatic ductal adenocarcinoma (PDAC) is a complex disease characterized by a dismal prognosis. The 5-year survival rate of 12% constitutes one of the lowest of all tumor entities 1 and with...

WebJan 24, 2024 · This Banbury Center meeting convened experts to discuss our current understanding of cancer-associated fibroblast (CAF) biology, with an emphasis on … http://perspectives09.myocaf.com/pottery_static_gallery/Fro_dest2/pages/Rick%20Berman.htm

WebActivation of CXCR2 by CXCL3 induced a CAF-to-myoCAF transition and α-smooth muscle actin (α-SMA) was uniquely upregulated by the CXCL3–CXCR2 signalling. Type III collagen was identified as the CXCL3–CXCR2-targeted adhesive molecule responsible for myoCAF-driven PDAC metastasis.ConclusionsOur work provides novel mechanistic insights into ...

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