Myocaf
WebApr 11, 2024 · Growing evidence demonstrates that cancer-associated fibroblasts (CAF) are responsible for tumor genesis, growth, metastasis, and treatment response. Therefore, targeting these cells may contribute to tumor control. It has been proposed that targeting key molecules and pathways of proliferative functions can be more effective than killing … WebDec 1, 2024 · Myofibroblastic CAF (myoCAF) are analogous to myofibroblasts found in wound-healing and tissue fibrosis. These contractile, secretory cells are regulated through TGFβ1 signaling, express α-smooth muscle actin (SMA), and secrete collagen-rich extracellular matrix (ECM; refs. 2, 3 ).
Myocaf
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WebOct 26, 2024 · According to the previous researches, 10 markers of myoCAF (ACTA2, TAGLN, MMP11, MYL9, HOPX, POSTN, TPM1, TPM2, IGFBP7, and CST1) and 10 markers of iCAF (PLA2G2A, CCDC80, MCL1, S100A10, LMNA, UAP1, DPT, ABL2, EFEMP1 and TNFAIP6) were selected in TCGA-THCA dataset.
http://perspectives09.myocaf.com/pottery_static_gallery/Fro_dest2/pages/Anne%20Rafferty.htm WebMar 23, 2024 · Main Pancreatic ductal adenocarcinoma (PDAC) is a complex disease characterized by a dismal prognosis. The 5-year survival rate of 12% constitutes one of the lowest of all tumor entities 1 and with...
WebJan 24, 2024 · This Banbury Center meeting convened experts to discuss our current understanding of cancer-associated fibroblast (CAF) biology, with an emphasis on … http://perspectives09.myocaf.com/pottery_static_gallery/Fro_dest2/pages/Rick%20Berman.htm
WebActivation of CXCR2 by CXCL3 induced a CAF-to-myoCAF transition and α-smooth muscle actin (α-SMA) was uniquely upregulated by the CXCL3–CXCR2 signalling. Type III collagen was identified as the CXCL3–CXCR2-targeted adhesive molecule responsible for myoCAF-driven PDAC metastasis.ConclusionsOur work provides novel mechanistic insights into ...
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