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Webeffect is a fall in blood pressure unaccompanied by a clinically significant change in cardiac output, heart rate, renal blood flow and glomerular filtration rate. There is no measurable negative chronotropic effect. In clinical studies to date, prazosin hydrochloride has not increased plasma renin activity. WebPrazosin has been proven to be safe and effective in the management of nightmares and sleep disturbances associated with PTSD and is indicated where these distressing symptoms are present. Post-traumatic stress disorder (PTSD) is a common disorder, affecting 3–4% of the general population. 1 The incidence of PTSD is higher in certain … WebSerious Side Effects: Syncopal episodes (in ~1% @ doses >2mg) Side Effects: dizziness, sedation/somnolence, lightheadedness, orthostatic ... The manufacturer reports that small amounts are excreted into human milk which is c/w prazosin's molecular weight. The effects on a nursing infant from exposure to the drug from breast milk are unknown. portofino strand hotel